Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-04-04
1992-05-12
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
564469, 564485, 564501, C07C31922, C07C32327
Patent
active
051129957
ABSTRACT:
A potassium salt useful in the production of N-substituted-1-alkylthio-2-nitroethenamines is produced by the reaction of the dipotassium salt of nitrodithioacetic acid with certain straight chain alkylamines, thereby converting only one of the KS-groups to an alkylamine group. The resulting monopotassium salt may be alkylated to produce the required N-substituted-1-alkylthio compound which may be reacted with a suitable amine to produce the histamine H.sub.2 -antagonist ranitidine.
REFERENCES:
Chemical Abstract 112(7), Feb. 12, 1990, Abstract No. 54989d.
Grayson James I.
Heyes Graham
Jackson Arthur
Rowney Paul E.
Glaxo Group Limited
Raymond Richard L.
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