Preparation of substituted aromatic compounds

Details Preparation of substituted aromatic compounds Preparation of substituted aromatic compounds

2006-04-04

2006-04-04

Davis, Zinna Northington (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S139000, C546S152000, C546S339000, C546S345000, C546S348000

Reexamination Certificate

active

07022857

ABSTRACT:
A process for preparing compounds of the formula (II),where the substituents R1to R5are each independently H, CH3, straight-chain or branched C1–C8-alkyl, CH(OC1–C5-alkyl)2, CH(C1–C5-alkyl)(OC1–C5-alkyl), CH2(OC1–C5-alkyl), CH(CH3)(OC1–C5-alkyl), C1–C8-alkoxy, N(C1–C5-alkyl)2, phenyl, substituted phenyl, aryl, heteroaryl, S(C1–C5-alkyl) or a radical Caryl, alkyl, andthe symbols X1 to 5are each carbon or a maximum of two neighboring X1-5are nitrogen or X1R1and X2R2together are O, NH, N(C1–C5-alkyl), N(C═O—C1–C5-alkyl), N(SiR3)2or S,or where neighboring radicals R1to R5form the following structural unit,where X6to X9and R6to R9have the same meaning as X1to X5and R1to R5which comprises reacting chloro- or fluoroaromatics of the formula (I) with carbon electrophiles and lithium metal.

REFERENCES:
patent: 4398037 (1983-08-01), Takeda et al.
patent: 5626798 (1997-05-01), Schwindeman
patent: 6392047 (2002-05-01), Geissler et al.
patent: 955291 (1999-10-01), None
patent: WO 92 19622 (1992-11-01), None
Hart et al., Organic Chemistry, Chapt 4.10, pp 125-126.
Guijarro, D et al., “Arene-Catalysed Lithiation of Fluoroarenes”, Elsivier Sci. Pub., (Feb. 2000), vol. 56, No. 8, pp 1135-1138, Amsterdam, NL.
Beilstein On-line, Database No. 4558685 Reaction-ID XP002263418 & J. Org. Chem, vol. 61. 1996, pp 7922-7926, Frankfurt am Main, DE.
Beilstein On-line, Database No. 4691904 Reaction-ID XP002263419 & J. Org. Chem, vol. 62, 1997, pp 3315-3323, Frankfurt am Main, DE.
Beilstein On-line, Database No. 665578 Reaction-ID XP002263421 & J. Am. Chem Soc., vol. 80, 1958, pp 4976-4977, Frankfurt am Main, DE.
Beilstein On-line, Database No. 654215 Reaction-ID XP002263422 & J. Org. Chem, vol. 19. 1954, pp 817-819, Frankfurt am Main, DE.
Guijarro, A, et al., “Naphthalene-Catalysed Lithiation of Functionalized Chlorarenes”, Tetrahedron, vol. 49, No. 2, 1993, pp 469-482.

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