Preparation of substituted 2-aminopyrazines

Details Preparation of substituted 2-aminopyrazines Preparation of substituted 2-aminopyrazines

1979-04-06

1980-07-08

Tovar, Jose

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424250, C07D24120

Patent

active

042118700

ABSTRACT:
Preparation of substituted 2-aminopyrazines by reaction of an .alpha.-chloro or .alpha.-bromo oxime with an aminoacetonitrile in the presence of an acid-uptake agent, followed by separation of the intermediate novel hydroxyimino-substituted aminoacetonitrile, and cyclization thereof with acid.

REFERENCES:
Sharp et al., J. Chem. Soc. 932 (1951).
Taylor et al., J. Am. Chem. Soc. 90, 2424, (1968).
Taylor et al., J. Am. Chem. Soc. 95, 6407-6412, (1973).
Lang et al., Tetrahedron Letters 3967-3970, (1974).
Masaki et al., Bull. Chem. Soc. Japan 36, 922 (1963).
Masaki et al., J. Org. Chem. 29, 3165, (1964).
Masaki et al., Bull. Chem. Soc. Japan 39, 2745 (1966).

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