Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1982-04-28
1983-10-11
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
435182, 435240, 435241, 424 93, 424DIG7, C12N 1110, C12N 1104, C12N 500, C12N 502
Patent
active
044093314
ABSTRACT:
Disclosed is a system and process for producing substances produced in cells such as antibodies and biological response modifiers. Cells which produce the substance of interest are encapsulated within semipermeable membranes having an upper limit of permeability sufficient to allow traverse of ions, amino acids and other cell nutrients and then suspended in a culture medium. Serum components or other high molecular weight materials needed for ongoing viability and normal in vitro metabolism of certain types of cells may be included within the intracapsular volume and may be excluded from the extracapsular medium by limiting the permeability of the membranes. The substance of interest collects either in the intracapsular volume or the extracapsular medium, depending on the degree of permeability of the membranes and on the molecular weight of the substance.
REFERENCES:
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patent: 3725113 (1973-04-01), Chang
patent: 3730841 (1973-05-01), Salvatore et al.
patent: 3733205 (1973-05-01), Shovers et al.
patent: 3827565 (1974-08-01), Matsumura
patent: 3860490 (1975-01-01), Guttag
patent: 4138292 (1979-02-01), Chibata et al.
patent: 4251387 (1981-02-01), Cim et al.
Kierstan et al., The Immobilization of Microbial Cells, Subcellular Organelles and Enzymes in Calcium Alginate Gels, Biotech. and Bioeng., vol. XIX, 1977, (pp. 387-397).
Tze et al., Implantable Artificial Endocrine Pancreas Unit Used to Restore Normoglycemia in Diabetic Rat, Nature, vol. 264, 1976, (pp. 466-467).
Chang, T. M. S., Biomedical Applications of Immobilized Enzymes and Proteins, vol. I, Plenum Press, N.Y., 1977, pp. 69-90 and 147-153.
Damon Corporation
Naff David M.
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