Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1988-05-06
1990-04-03
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424 11, 424 71, 424486, 424487, 42721331, 42721334, 42840222, 514965, 526297, A61K 950, A61K 918, A61K 952
Patent
active
049139088
ABSTRACT:
Process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active substance.
At least one alkyl cyanoacrylate, in which the term "alkyl" denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another water-soluble substance, and the stirring is continued until substantially all the alkyl cyanoacrylate has been converted to submicroscopic particles formed of polyalkyl cyanoacrylate; a biologically active substance is introduced into the reaction medium before the introduction of the monomer or after formation of the submicroscopic particles.
The submicroscopic particles are useful as carriers for substances such as medical substances or products for diagnosis.
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Couvreur Patrick
Roland Michel
Speiser Peter
Lovering Richard D.
N. V. Sopar S.A.
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