Preparation of stable zinc insulin analog crystals

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides

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514 3, A61K 3828, C07K 1462

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active

055041884

ABSTRACT:
The present invention discloses a process of preparing a crystalline insulin analog. The process is useful in the purification and manufacture of Lys.sup.B28 Pro.sup.B29 -human insulin. Lys.sup.B28 Pro.sup.B29 -human insulin is useful in the treatment of diabetes.

REFERENCES:
patent: 2143590 (1939-01-01), Scott et al.
patent: 2626228 (1953-01-01), Petersen
patent: 2920014 (1960-01-01), Petersen et al.
patent: 3719655 (1973-03-01), Jackson
patent: 4959351 (1990-09-01), Grau
patent: 5028587 (1991-07-01), Dorschug et al.
patent: 5149777 (1992-09-01), Hansen et al.
patent: 5164366 (1992-11-01), Balschmidt et al.
Fullerton, et al., Biochim, Biophys. Acta, 214, 141-147 (1970).
Diabetologia, 30, 503A (1987).
Brange, et al., Nature, 333:16, 679-682 (Jun. 1988).
Brange, et al., Diabetes Care, 13:9, 923-954 (Sep. 1990).
Brange, et al., Structural Biology, 1, 934-940 (1991).
Brange, Galenics of Insulin: The Physico-chemical and Pharmaceutical Aspects of Insulin and Insulin Preparations, Springer-Verlag Berlin Heidelberg, Germany (1987).
Scott, Biochemical Journal, 28:4, 1592-1602 (Apr. 28, 1934).
Brems, et al., Protein Engineering, 5:6, 527-533 (1992).
Wollmer, et al., Biol. Chem. Hoppe-Seyler, 370, 1045-1053 (Sep. 1989).
Wollmer, et al., Phenol-Promoted Structural Transformation of Insuline in Soluntionfrom the 2nd Assisi International Symposium on Advanced Models for the Therapy of Insulin-Dependent Diabetes, 903-911 (Apr. 1986).
Harding, et al., The Crystal Structure of Insulin: II. An Investigation of Rhombohedral Zinc Insulin Crystals and a Report of Other Crystalline Forms Chemical Crystallography Laboratory, South Parks Road, Oxford, England (Nov. 8, 1965).
Derewenda, et al., Nature, 338, 594-596 (Apr. 13, 1989).
Brems, et al., Protein Engineering, 5:6, 519-525 (1992).
Howey, et al., Diabetes, 43, 396-402 (Mar. 1994).
Diabetes, 41, Suppl. 1, 192A (1992).
Brems, et al., Protein Engineering, 5:6, 519-525 (1992).
Heinemann, et al., Diabetologia, 33, 384-386 (1990).
Kirk-Othmer, Encyclopedia of Chemical Technology 13, 607-614 (1981).
Bruce H. Frank, Text aned Slide copies of lecture given at the Conference on Insulin, Self Association and Conformational Studies on Human Proinsulin and Insulin Analogs, University of York, Aug. 29-Sep. 1, 1989.

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