Preparation of stable formulations of lipid-nucleic acid complex

Details Preparation of stable formulations of lipid-nucleic acid complex Preparation of stable formulations of lipid-nucleic acid complex

1997-11-10

2000-06-06

Ketter, James

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127

Patent

active

060715332

ABSTRACT:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab' fragment attached to a hydrophilic polymer.

REFERENCES:
patent: 5783210 (1998-07-01), Tremblay et al.

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