Preparation of specifically substituted cyclodextrins

Details Preparation of specifically substituted cyclodextrins Preparation of specifically substituted cyclodextrins

1990-06-28

1992-12-22

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, C08B 3716, A61K 3170

Patent

active

051734818

ABSTRACT:
A process for producing monosubstituted alpha-, beta-, and gamma-cyclodextrins includes the step of condensing an excess of a cyclodextrin with an epoxide under alkaline conditions. A process for increasing the solubility of cyclodextrins includes the step of reacting a cyclodextrin with an amine under heterogenous catalytic conditions, or subjecting the cyclodextrin to sulfatation. Compositions useful in these processes include one containing at least one cyclodextrin, ammonia and Raney nickel, and a second composition containing at least one cyclodextrin, chlorosulfonic acid and pyridine.

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patent: 4840941 (1989-06-01), Ueno et al.
patent: 4877778 (1989-10-01), Carpenter et al.
patent: 4912093 (1990-03-01), Michaeli
patent: 5019562 (1991-05-01), Folkman et al.

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