Preparation of sodium chloride aerosol formulations

Details Preparation of sodium chloride aerosol formulations Preparation of sodium chloride aerosol formulations

1995-04-05

1998-05-05

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, 424489, 424680, 514937, 514951, A61K 912

Patent

active

057470022

ABSTRACT:
Disclosed herein is a method for the preparation of sodium chloride formulations having a substantially uniform particle size suitable to ensure the dispersible properties for inhalation into the lungs of a subject. The formulations thus prepared are also the subject of this disclosure. The method involves jet milling coarse sodium chloride in one or preferably two or more procedures using air pressure suitable to produce particles having a significant fraction that are less than about 7 microns in size. Immediately following the milling, the particles are vacuum dried in an oven using a temperature and time suitable to cure the product to prevent substantial aggregation over time.

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