Preparation of sodium cefuroxime

Details Preparation of sodium cefuroxime Preparation of sodium cefuroxime

1980-02-14

1981-07-07

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 20, C07D50134

Patent

active

042776015

ABSTRACT:
A process for the preparation of the sodium salt of the antibiotic (6R,7R)-3-carbamoyloxymethyl-7-[Z-2-(fur-2-yl)-2-methoxyiminoacetamido]-ce ph-3-em-4-carboxylic acid (cefuroxime) which comprises subjecting a corresponding 3-N-protected carbamoyloxymethyl compound to alcoholysis in a substantially anhydrous medium using a basic catalyst comprising the sodium salt of an acid having a pK.sub.a value of not less than 3.5 whereby sodium cefuroxime or a solvate thereof can be obtained directly without isolation of the corresponding acid. Sodium cefuroxime tetrahydrofuran solvate is also provided as a new entity.

REFERENCES:
patent: 3905963 (1975-09-01), Webber
patent: 3974153 (1976-08-01), Cook et al.
patent: 4128715 (1978-12-01), Sharp

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