Preparation of serum standard for radioassay of thyroxine

Details Preparation of serum standard for radioassay of thyroxine Preparation of serum standard for radioassay of thyroxine

1976-06-18

1978-01-24

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

23230B, 232303, 424 1, G01N 3316

Patent

active

040701530

ABSTRACT:
Thyroxine binding globulin (TBG) and thyroxine (T.sub.4) can be efficiently removed fron serum containing TBG and T.sub.4 by contacting the serum with finely-divided alumina particles to adsorb a major portion of the T.sub.4 and then reacting the serum at an acidic pH with an anion exchange resin to extract substantially all TBG and the remaining T.sub.4.

REFERENCES:
patent: 3666854 (1972-05-01), Eisentraut
patent: 3743482 (1973-07-01), Eisentraut
patent: 3775615 (1973-11-01), Eisentraut
patent: 3947564 (1976-03-01), Shannon
patent: 3962039 (1976-06-01), Bates
patent: 3970746 (1976-07-01), Premachandra
patent: 4005187 (1977-01-01), Kilthau
Ingbar et al., Endocrinology, vol. 61, pp. 321-326, (1957).

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