Preparation of salts of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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Reexamination Certificate

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06943251

ABSTRACT:
In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.

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Bruzik, Karol, “Chapter 6: Conformation”, Department of Medicinial Chemistry, University of Illinois at Chicago, [online] Nov. 10, 1998, [retrieved on Dec. 21, 2004]. Retrieved from the Internet, <http://tigger.uic.edu/˜kbruzik/text/chapter6.html>.
Clark Landis et al, “What does Chemistry have to do with AIDS?”, Chemistry Department, University of Wisconsin [online] no date, [retrieved on Dec. 12, 2004]. Retd from the internet, <http://wwwchem.wisc.edu/˜newtrad/CurrRef/AIDStopic/AIDStext/AIDSpp1.html.>.
Paul M. Lahti, “Structural Analysis of Simple Amide”, Department of Chemistry—U Mass. at Amherst [online] Aug. 11, 1998, [retrieved on Dec. 22, 2004]. Retrieved from the internet, <http://www..chem.umass.edu/˜nermmw/amide.html>.
Shriner, Ralph Lloyd, Fuson, Reynold C., and Curtin, David Y. “The Systematic Identification of Organic Compounds”, New York: J. Wiley & Sons, 1956, p. 224.
S. Berge et al., “Pharmaceutical Salts”,J. of Pharmaceutical Sciences,66(1): 1-19 (1977).
P. Gould, “Salt Selection for Basic Drugs”,International J. of Pharmaceutics,33: 201-217 (1986).

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