Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-but

Details Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-but Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-but

1996-02-20

1996-12-24

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546147, 546116, 546 97, C07D21716

Patent

active

055874819

ABSTRACT:
Methods for preparing (S)-N-tert-butyl-1,2,3,4-tetrahydro-3-isoquinoline-carboxamide ("tic-c"), and converting tic-c to (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide ("tic-d") are disclosed. The initial step in the formation of tic-c involves the phosgenation of a substituted tetrahydroisoquinoline to form an N-carboxy anhydride. Tic-d is used as an intermediate in the synthesis of known compounds having pharmaceutical activity.

REFERENCES:
patent: 5157041 (1992-10-01), Handa et al.
patent: 5196438 (1993-03-01), Martin et al.
patent: 5256783 (1993-10-01), Gokhal et al.
patent: 5380849 (1995-01-01), Houpis et al.
E. C. Weir, et al., Tricyclic Hydantoins and Thiohydantoins of Phenylalanine, Chimika Chronika, New Series, vol. 18, No. 1, pp. 3-17 (Mar. 1989).

Affiliated with

Also associated with

Rating

Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-but does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-but, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-but will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1179466