Preparation of S-chloromethylated O-alkyl substituted phosphodit

Details Preparation of S-chloromethylated O-alkyl substituted phosphodit Preparation of S-chloromethylated O-alkyl substituted phosphodit

1979-12-04

1981-04-28

Sutto, Anton H.

Chemistry of carbon compounds

Dipeptides, e.g., aspartame, anserine, carnosine, etc.

260963, C07F 9165

Patent

active

042645336

ABSTRACT:
A novel and efficient method for preparing S-chloromethyl derivatives of O-alkylphosphorodithioic acids involves reacting the S-hydroxymethyl derivative of such an acid under substantially anhydrous conditions with a suitable acid chloride in a chemically unreactive organic liquid which is a solvent for both said S-hydroxymethyl derivative and said acid chloride. Suitable acid chlorides are PCl.sub.5, PCl.sub.3, acetyl chloride, chlorinated derivatives of acetyl chloride, oxyalyl chloride, phosgene, thionyl chloride, sulfuryl chloride, aryl sulfonyl chlorides and chloro- or nitro-substituted aryl sulfonyl chlorides.

REFERENCES:
patent: 2092712 (1937-09-01), Clifford
patent: 3020304 (1962-02-01), Scherer et al.
patent: 3052709 (1962-09-01), Strube et al.
patent: 3669981 (1972-06-01), Pera
patent: 3896219 (1975-07-01), Pianka
Sexton et al. "J. of Chem. Soc.", (London), (1948) p. 1717.
Dolman et al. "Rec. des Travaux Chem. des Pays-Bas", vol. 88 (1969), pp. 417-424.

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