Preparation of rhenium phosphonate therapeutic agents for bone c

Details Preparation of rhenium phosphonate therapeutic agents for bone c Preparation of rhenium phosphonate therapeutic agents for bone c

1989-05-02

1991-06-04

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

423249, 534 10, A61K 4300, C01G 4700

Patent

active

050212354

ABSTRACT:
The process of the present invention includes preparing a first aqueous solution of rhenium in the form of radioactive perrhenate, wherein the concentration of rhenium in said solution is within the range of about 5.times.10.sup.-6 M to about 2.times.10.sup.-3 M, and then reducing and complexing the radioactive perrhenate by mixing a second solution or lyophilized solid with the first solution. The second solution or lyophilized solid comprises a ligand which complexes with the radioactive perrhenate and a reductant wherein the reductant is present in the second solution at a concentration in the range of about 0.005M to about 0.020M and the ligand is present in the second solution at a concentration in the range of about 0.01M and about 0.15M. The pH of the resultant solution is within the range of about 1.5 to about 5.5.

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