Preparation of retrovirus-free immunoglobulins

Details Preparation of retrovirus-free immunoglobulins Preparation of retrovirus-free immunoglobulins

1986-04-08

1988-08-09

Siegel, Alan

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424 85, 424 89, 435236, 530387, 514 2, A61K 3514, A61K 39395, C07K 1506, C12N 900

Patent

active

047627140

ABSTRACT:
Immune serum globulins (ISG) can be made substantially free of infectious retroviruses by preparing the ISG from human plasma using a cold ethanol plasma fractionation process at a pH equal to or less than 5.4 and then storing the ISG at either of two specified storage conditions: (1) at a pH equal to or less than about 4.25 at a temperature of about 27.degree. C. for at least 3 days, or (2) at a pH equal to or less than about 6.8 at a temperature of about 45.degree. C. for at least about 8 hours. pg,10

REFERENCES:
patent: 2897123 (1959-07-01), Singher
patent: 4396608 (1983-08-01), Tenold
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4640834 (1987-02-01), Eibl et al.

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