Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-05-09
1990-08-14
Stone, Jacqueline M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424 858, 424530, 435236, 514 2, C07K 1506, C12N 900, A61K 3514, A61K 39395
Patent
active
049488775
ABSTRACT:
Immune serum globulins (ISG) can be made substantially free of infectious retroviruses by storing the ISG in a liquid state at conditions of pH, temperature and time sufficient to inactivate substantially all infectious retroviruses. Preferred inactivation methods involve use of either of two specified storage conditions: (1) at a pH equal to or less than about 4.25 at a temperature of about 27.degree. C. for at least 3 days, or (2) at a pH equal to or less than about 6.8 at a temperature of about 45.degree. C. for at least about 8 hours.
REFERENCES:
patent: 2897123 (1959-07-01), Singher
patent: 4396608 (1983-08-01), Tenold
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4640834 (1987-02-01), Eibl et al.
Mitra Gautam
Mozen Milton M.
Giblin James A.
Miles Laboratories Inc.
Stone Jacqueline M.
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