Preparation of quinoxaline compounds

Details Preparation of quinoxaline compounds Preparation of quinoxaline compounds

2007-10-30

2007-10-30

Tucker, Zachary C (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S116000, C540S552000, C540S593000, C540S599000

Reexamination Certificate

active

10910983

ABSTRACT:
Certain methods are disclosed that are useful in the preparation of CCK2 active amidophenyl-sulfonylamino-quinoxaline compounds of the formula:wherein R1, R2, Raand Rbare defined.

REFERENCES:
patent: 5847125 (1998-12-01), McDonald
patent: 6239131 (2001-05-01), Shinozaki et al.
patent: 2005/0038032 (2005-02-01), Allison et al.
patent: WO95/04720 (1995-02-01), None
Hawley's Condensed Chemical Dictionary, p. 587, © 1997 by Van Nostrand Reinhold.
Vippagunta et al, “Crystalline Solids” Advanced Drug Delivery Reviews, vol. 48, pp. 3-26 (2001).
Gavezzotti, “Are Crystal Structures Predictable?” Accounts of Chemical Research, vol. 27, pp. 309-314 (1994).
Black, J.W. and S.B. Kalindjian. Gastrin Agonists and Antagonists. Pharmacol. Toxicol. 2002, 91:275-281.
de Tullio, P. et al. Therapeutic and Chemical Developments of Cholecystokinin Receptor Ligands. Exp. Opin. Invest. Drugs 2000, 9(1):129-146.
Herranz, R. Cholecystokinin Antagonists: Pharmacological and Therapeutic Potential. Med. Res. Rev. 2003, 23(5):559-605.
McDonald, I.M. CCK2 Receptor Antagonists. Exp. Opin. Ther. Patents. 2001, 11(3):445-462.
Morton, M.F. et al. Pharmacological Comparison of the Alternatively Spliced Short and Long CCK2 Receptors. Br. J. Pharmacol. 2003, 140(1):218-224.
Revel, L. and F. Makovec. Update on Nonpeptide CCK-B Receptor Antagonists. Drugs Future. 1998, 23(7):751-766.
Tracy, H.J. and R.A. Gregory. Physiological Properties of a Series of Peptides Structurally Related to Gastrin 1. Nature (London). 1964, 204:935-938.
Varnavas, A. et al. Anthranilic Acid Based CCK1 Antagonists: The 2-Indole Moiety May Represent a “Needle” According to the Recent Homonymous Concept. Eur. J. Med. Chem. 2004, 39:85-97.
Varnavas, A. et al. Synthesis of N-Terminal Substituted Anthranilic Acid Dimer Derivatives for Evaluation on CCK Receptors. II Farmaco. 2001, 56:555-564.
PCT International Search Report, dated Dec. 15, 2004, for PCT Int'l. Appln. No. PCT/US2004/025154.
Varnavas, Antonio et al., “Anthranilic Acid Derivatives: A New Class fo Non-Peptide CCK1 Receptor Antagonists”, Biorganic & Medicinal Chemistry, Elsevier Science Ltd., GB, vol. 11, No. 5, Mar. 2003, pp. 741-751.

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