Preparation of pyrrolidine and pyrrolidin-2-one derivatives

Details Preparation of pyrrolidine and pyrrolidin-2-one derivatives Preparation of pyrrolidine and pyrrolidin-2-one derivatives

1978-02-08

1979-11-06

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265C, 2603265M, 424274, C07D20726

Patent

active

041735692

ABSTRACT:
Preparation of compounds of the formula: ##STR1## wherein n is 1, 2 or 3, R.sub.1 and R.sub.2, which may be the same or different, are hydrogen or alkyl containing 1 to 3 carbon atoms and the asterisk indicates the center of asymmetry of the molecule, and compounds of the formula ##STR2## wherein R" is a saturated or unsaturated aliphatic hydrocarbon containing 1 to 6 carbon atoms, R.sub.3 is hydrogen or acyl containing 1 to 7 carbon atoms and the asterisk indicates the center of asymmetry of the molecule. The compounds produced by the present invention improve learning memory and display a protecting effect against the E.E.G. consequence of an overdose of barbiturates and against the reduced performance following brain damage (e.g. cerebral edema).

REFERENCES:
Aantaa, E., et al, J. Int. Med. Res., (1975) 3, pp. 352-356.

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