Preparation of purified optical isomers of desflurane

Details Preparation of purified optical isomers of desflurane Preparation of purified optical isomers of desflurane

1993-04-15

1994-02-01

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 4122

Patent

active

052833720

ABSTRACT:
A process for the preparation of highly purified optical isomers of desflurane, i.e. 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane, is described wherein the highly purified opposite optical isomer of iso-flurane is reacted with bromine trifluoride in the cold, preferably in the presence of a solvent. A preferred solvent is bromine. The highly purified positive isomer of desflurane is advantageous over the negative isomer or the racemate.

REFERENCES:
patent: 4762856 (1988-08-01), Terrell
patent: 5015781 (1991-05-01), Robin et al.
patent: 5114714 (1992-05-01), Young et al.
patent: 5114715 (1992-05-01), Young et al.

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