Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-01-10
1997-04-29
Elliott, George C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 435 13, C07K 400, C12Q 156
Patent
active
056250363
ABSTRACT:
A prothrombin time reagent is disclosed for use in a prothrombin time test. The reagent utilizes recombinant human tissue factor, phospholipids of a natural or synthetic origin, a buffer composition and calcium ion. Stabilizers and salts may also be utilized in the reagent. In addition, a method for creating lipid micelles containing tissue factor is also disclosed.
REFERENCES:
patent: 4461833 (1984-07-01), Gordon
patent: 4721572 (1988-01-01), Jordan
patent: 4865984 (1989-09-01), Nemerson et al.
patent: 5439802 (1995-08-01), Rosen
Prothrombin Time Reagents Prepared from Recombinant Human Tissue Factor Produced in E coli. P. Hawkins et al. Thrombosis and Haemostasis (1991) 645-1417 vol. 65(6).
Biochemistry 25 (14) 1986; 4007-4020. Bach, R. "Factor VII binding to tissue factor in reconstituted phospholipid vesicles: Induction of cooperativity by phosphatitidylserine."
Dade.sup.R Thromboplastin IS, Dried Rabbit Brain Thromboplastin with Calcium. Baxter Healthcare Corp. 1989.
Dade.sup.R Thromboplastin C Plus, Dried Rabbit Brain Thromboplastin with Calcium. Baxter Healthcare Corp. 1990.
Dade.sup.R Thromboplastin C, Dried Rabbit Brain Thromboplastin with Calcium. Baxter Healthcare Corp. 1989.
Nemerson, Y. "Tissue Factor and Hemostasis", Blood: 71 1, 1-8 (1988).
Paborsky, Lisa R. et al., "Purification of Recombinant Tissue Factor", Biochemistry; 28 20, 8072-8077 (1989).
Spicer, Eleanor K. et al., "Isolation of cDNA cones coding for human tissue factor: Primary structure of the protein and cDNA", Proceedings of the National Academy of Science; 84, 5148-5152 (1987).
Bach, Ronald, "Initiation of Coagulation by Tissue Factor", CRC Critical Reviews in Biochemistry; 23 4, 339-368 (1988).
Bach, Ronald et al., "Prufification and Characterization of Bovine Tissue Factor", Journal of Biol. Chem.; vol. 256 16, 8324-8331 (1981).
Brown, Scott M. et al., "Development of a human Recombinant Tissue Factor Prothrombin Time Reagent", Clin. Chem.; 37 6, 951 (1991).
Chargaff, Erwin, et al., "The Thromboplastic Protein: Structure Properties, Disintegration", J. biol. Chem; 156, 161-178 (1944).
Fisher, Karen et al., "Cloning and Expression of Human Tissue Factor cDNA", Thrombosis Research; 48, 89-99 (1987).
Lawson, Jeffrey H. & Mann, Kenneth G. "Cooperative Activation of Human Factor IX by the Human Extrinsic Pathway of Blood Coagulation" J. Biol. Chem; 266 17, 11317-11327 (1991).
Roy et al. Journal of Biochemistry, 266:4665-4668. 1991.
Scarpati et al. Biochemistry, 26:5234-5238. 1984.
Liang et al. Biochemical and Biophysical Research Communications, 137:847-854. 1986.
Ruf et al. Journal of Biological Chemistry, 266:2158-2166. 1991.
Wang et al. Biochemical Journal, 276:63-71. 1991.
Rehemtulla et al. Thrombosis and Haemostasis, 65:521-527. 1991.
Hawkins Pamela L.
Johnson Kevin B.
Maynard James
Tejidor Liliana
Dade International Inc.
Elliott George C.
Tymeson Cynthia
Wai Thanda
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