Preparation of protein microparticles by supercritical fluid pre

Details Preparation of protein microparticles by supercritical fluid pre Preparation of protein microparticles by supercritical fluid pre

1991-11-14

2000-05-16

Woodward, Michael P.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

424 44, 424 45, 424489, 264 5, 426425, 514 2, 530350, A61K 914

Patent

active

060639105

ABSTRACT:
The present invention comprises passing a solution of a soluble material, preferably a protein, in a solvent through a continuum of supercritical antisolvent fluid and precipitating the soluble material. This can be conducted by passing the solution through the continuum of supercrital fluid in the form of droplets, which can be sprayed through the supercritical fluid. The plurality of droplets can be passed cocurrently or countercurrently with respect to a stream of antisolvent fluid. Alternatively, the solution can be passed through the continuum of supercritical antisolvent fluid in the form of a thin film or a plurality of fine streams.

REFERENCES:
patent: 3773919 (1973-11-01), Boswell
patent: 4263253 (1981-04-01), Pilz
patent: 4985270 (1991-01-01), Singer
patent: 4990355 (1991-02-01), Gupta
patent: 5013713 (1991-05-01), Mitchell
patent: 5043280 (1991-08-01), Fischer
patent: 5169968 (1992-12-01), Rice
patent: 5301664 (1994-04-01), Sievers
patent: 5639441 (1997-06-01), Sievers
patent: 5814678 (1998-09-01), Randolph
patent: 5851453 (1998-12-01), Hanna
patent: 5904935 (1999-05-01), Eckenhoff
CA 111:216768. (1989).
Tom & Debenedetti, Formation of Bioerodible Polymeric Microspheres and Microparticles by Rapid Expansion of Supercritical Solutions, Dept of Chemical Engineering, Princeton University, 1991.
Chang & Randolph, Solvent Expansion and Solute Solubility Predictions in Gas-Expanded Liquids, AICHE Journal, Jun. 1990, vol. 36, No. 6, pp. 939-942.
Tavana AICHE Journal 35, 1625-1630, 1989.
Tom, J. Aerosol Sci 22, 555-584 1991.

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