Preparation of prostaglandin intermediates

Details Preparation of prostaglandin intermediates Preparation of prostaglandin intermediates

1974-06-24

1977-01-25

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603458, 2603459, 260468D, 260514D, C07D30783

Patent

active

040051099

ABSTRACT:
Preparation of prostaglandin intermediates by reacting mon-tetrahydropyranyl ether, in a diethyl ether medium containing pyridine, with malonyl dichloride, reacting the resulting malonic acid chloride with triethylamine in a diethyl ether medium to produce a ketone derivative, followed by heating to effect ring closure, then reduction, then cleaving the cyclobutyl ring followed by epimerization to produce the "Corey" intermediate. Those intermediates which are novel are also claimed.

REFERENCES:
patent: 2268169 (1941-12-01), Sauer
patent: 3711515 (1973-01-01), Kelly
patent: 3778461 (1973-12-01), Brown et al.
patent: 3781306 (1973-12-01), Kelly
patent: 3816460 (1974-06-01), Kelly
patent: 3816461 (1974-06-01), Kelly
patent: 3816462 (1974-06-01), Kelly
patent: 3818045 (1974-06-01), Kelly
patent: 3823138 (1974-07-01), Rheenen
Wagner et al., Syn. Org. Chem. p. 407 (1955).
J. Am. Chem. Soc. vol. 94 pp. 4014-4015 (1972).

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