Preparation of prostaglandin intermediates

Details Preparation of prostaglandin intermediates Preparation of prostaglandin intermediates

1974-06-24

1976-11-23

Williams, Howard S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

204158R, B01J 110, C07D30783, C07D30922

Patent

active

039936643

ABSTRACT:
Preparation of prostaglandin intermediates by reacting mono-tetrahydropyranyl ether with 3-acetoxy acryloyl chloride in the presence of pyridine to produce the 3-acetoxy acryloyl ester of said ether. The said ester is then irradiated to effect photocyclization whereby to close the ring in said ester. The resulting compound is then treated with methanol containing a small amount of potassium carbonate whereby to produce the "Corey" intermediate. Those intermediates which are novel are also claimed.

REFERENCES:
patent: 3711515 (1973-01-01), Kelly
patent: 3778461 (1973-12-01), Brown et al.
patent: 3781306 (1973-12-01), Kelly
patent: 3816460 (1974-06-01), Kelly
patent: 3816461 (1974-06-01), Kelly
patent: 3816462 (1974-06-01), Kelly
patent: 3818045 (1974-06-01), Kelly
patent: 3823138 (1974-07-01), Rheenen

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