Preparation of propranolol hydrochloride macrocrystals

Details Preparation of propranolol hydrochloride macrocrystals Preparation of propranolol hydrochloride macrocrystals

1985-05-21

1992-03-10

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C21732

Patent

active

050951513

ABSTRACT:
There is described a process for the preparation of high yields of propranolol hydrochloride having a particle size within the range of 420 to 1200 microns wherein the propanolol hydrochloride is recrystallized from, as a solvent, a mixture of n-propanol and heptane.
The propranolol hydrochloride macrocrystals are useful themselves in capsule pharmaceutical dosage forms and when coated with a sustained release coating composition, are useful in the manufacture of sustained action capsule and tablet pharmaceutical dosage.

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