Preparation of pregabalin and related compounds

Details Preparation of pregabalin and related compounds Preparation of pregabalin and related compounds

2010-11-22

2011-10-25

Kosack, Joseph (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C562S553000

Reexamination Certificate

active

08044227

ABSTRACT:
Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.

REFERENCES:
patent: 5563175 (1996-10-01), Silverman et al.
patent: 5599973 (1997-02-01), Silverman et al.
patent: 5608090 (1997-03-01), Silverman et al.
patent: 5616793 (1997-04-01), Huckabee et al.
patent: 5618710 (1997-04-01), Navia et al.
patent: 5629447 (1997-05-01), Huckabee et al.
patent: 5637767 (1997-06-01), Grote et al.
patent: 5684189 (1997-11-01), Silverman et al.
patent: 5710304 (1998-01-01), Silverman et al.
patent: 5840956 (1998-11-01), Grote et al.
patent: 5847151 (1998-12-01), Silverman et al.
patent: 6001876 (1999-12-01), Singh
patent: 6028214 (2000-02-01), Silverman et al.
patent: 6046353 (2000-04-01), Grote et al.
patent: 6127418 (2000-10-01), Bueno et al.
patent: 6194459 (2001-02-01), Akunne et al.
patent: 6242488 (2001-06-01), Bueno et al.
patent: 6306910 (2001-10-01), Magnus et al.
patent: 6326374 (2001-12-01), Magnus et al.
patent: 6329429 (2001-12-01), Schrier et al.
patent: 6359005 (2002-03-01), Pande
patent: 6359169 (2002-03-01), Silverman et al.
patent: 6426368 (2002-07-01), Bueno et al.
patent: 2003/0149172 (2003-08-01), Cao et al.
patent: 2003/0212290 (2003-11-01), Burk et al.
Anderson et al., One Biocatalyst-Many Applications: The Use ofCandida antarcticaB-Lipase in Organic Synthesis,Biocat. Biotransform. (1998), vol. 16, pp. 181-204.
Berge, et al, Pharmaceutical Salts,J. of Pharm. Sci., (1977), vol, 66, pp. 1-19.
Burk et al, An Enantioselective Synthesis of (S)-(+)-3-Aminomethy1-5-methylhexanoic Acid via Asymmetric Hydrogenation,J. Org. Chem., (2003), pp. 5731-5734, vol. 68.
Haleblian, Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applications,J. of Pharm. Sci., (1975), vol. 64, pp. 1269-1288.
Kato et al,Nippon Noqei Kaqaku Kaishi, (1953), p. 500, vol. 27 (In Japanese, translated to English).
Knabe, J. et al,Arch. Pharm, (1972), pp. 757-765, vol. 305 (In German, translated to English).
Knabe, J. et al,Tetrahedron Lett., (1973), pp. 745-746, vol, 10 (In German, translated to English).
Knabe, J,, et al.Arch. Pharm., (1984), pp. 353-362, vol. 317, No. 4.
Koeller et al., Enzymes for Chemical Synthesis,Nature, (2001), vol. 409, pp. 232-240.
Lopez-Serrano et al., Cross-linked Enzyme Aggregates with Enhanced Activity: Application to Lipases,Biotech. Lett., (2002), vol. 24, pp. 1379-1383.
Sammis et al, Highly Enantioselective, Catalytic Conjugate Addition of Cyanide to alpha, beta-Unsaturated Imides,J. Am. Chem. Soc., (2003), pp. 4442-4443, vol. 125.
Wilk, The Knoevenagel Condensation of O,S- and S,S-Diethyl Malonates and Ethyl Pyruvate,Tetrahedron, (1997), vol. 53, pp. 7097-7100.
Yazbeck et al., Automated Enzyme Screening Methods for the Perparation of Enantiopure Pharmacutical Intermediates,Synth. Catal., (2003), vol. 345, pp. 524-532.

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