Preparation of polypeptides having human .gamma.-interferon acti

Details Preparation of polypeptides having human .gamma.-interferon acti Preparation of polypeptides having human .gamma.-interferon acti

1985-03-04

1989-05-23

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

530351, 435 68, 435811, A61K 4502, C07K 1300, C12P 2100

Patent

active

048329592

ABSTRACT:
Partial sequences of human-.gamma.-interferon, comprising aminoacid sequences 5 to 127, 1 to 127 and 5 to 146, having biological activity. These partial sequences can be obtained by a genetic engineering process, for which purpose the appropriate DNA sequences are chemically synthesized. The DNA sequences are incorporated in hybrid plasmids, and the latter are introduced into host organisms and their expression is induced there. The biologically active polypeptides are suitable, as is human-.gamma.-interferon, for medicaments.

REFERENCES:
patent: 4457867 (1984-07-01), Ishida
patent: 4604284 (1986-08-01), Kung et al.
Devos et al., Nuclear Acid Research, vol. 10, pp. 2487-2501, 1982.
Gray et al., Nature, vol. 295, pp. 503-508, 1982.
Shepard et al., Nature, vol. 294, pp. 563-565, 1981.
Search Report issued in corresponding European Patent Application, EP 85 104 501.3.

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