Preparation of platinum (II) complexes

Details Preparation of platinum (II) complexes Preparation of platinum (II) complexes

2011-06-07

2011-06-07

Gonzalez, Porfirio Nazario (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C548S106000, C546S006000

Reexamination Certificate

active

07956208

ABSTRACT:
This invention relates a method for the preparation of platinum(II) oxalato complexes from their dihalogenoplatinum(II) precursors having either neutral monodentate or bidentate non-leaving co-ligands. Of particular interest is oxaliplatin. The method includes the step of reacting a halogenoplatinum(II) complex containing a neutral monodentate or bidentate ligand with an oxalate in a non-aqueous solvent or a mixed solvent system. The mixed solvent system is solvent mixture containing a non-aqueous solvent and water. According to the present invention, the non-aqueous solvent is an alcohol.

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