Preparation of phytosphingosine derivative

Details Preparation of phytosphingosine derivative Preparation of phytosphingosine derivative

1995-06-26

1997-04-08

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435101, 4352555, 435938, C12P 1300, C12N 116

Patent

active

056187068

ABSTRACT:
The invention concerns a process for preparing tetraacetylphytospingosine (TAPS) using F-60-10 mating type strain of Pichia ciferrii. Such strain is subjected to mutagenesis and the high TAPS producing strains are selected by a special procedure. These strains are grown in a fed batch mode on a non-fermentative carbon source at a temperature above 26.degree. C and the TAPS collected from the fermentation medium. Glycerol is a preferred carbon source and preferably L-serine is added to the culture medium.

REFERENCES:
patent: H001168 (1993-04-01), McKeena et al.
patent: 5262312 (1993-11-01), Holla et al.
patent: 5368857 (1994-11-01), Corcoran

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