Preparation of phosphorylated amidines

Details Preparation of phosphorylated amidines Preparation of phosphorylated amidines

1978-03-17

1979-07-24

Sutto, Anton H.

Chemistry of carbon compounds

Dipeptides, e.g., aspartame, anserine, carnosine, etc.

26032661, 544157, 546 21, C07F 924

Patent

active

041622804

ABSTRACT:
Preparation of a phosphorylated amidine of the formula ##STR1## wherein X is oxygen or sulfur and R, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are various organic radicals, which comprises reacting a phosphoric acid ester-amide of the formula ##STR2## with a carboxamide of the formula ##STR3## at a temperature between about 0.degree. and 50.degree. C., and then reacting the mixture with a base. Advantageously the reaction is effected at about 0.degree. to 15.degree. C. in the presence of an aliphatic or aromatic optionally chlorinated hydrocarbon or an alcohol as an inert solvent, and in the presence of a catalyst.

REFERENCES:
patent: 2965667 (1960-12-01), Tolkmith
patent: 3801679 (1974-04-01), Hoffman et al.
patent: 3888951 (1975-06-01), Hoffman et al.
patent: 4000268 (1976-12-01), Sirrenberg et al.
Chem. Ber. 101,1 (1968) pp. 41-50.

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