Preparation of pharmacologically active hydroxyalkyl starch

Details Preparation of pharmacologically active hydroxyalkyl starch Preparation of pharmacologically active hydroxyalkyl starch

1975-10-06

1977-04-05

Marquis, Melvyn I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C08B 3108

Patent

active

040163547

ABSTRACT:
Hydroxyalkyl starch having utility as a cryoprotective agent for human errocytes and as a plasma volume expander is prepared by the steps of subjecting a waxy starch to acid hydrolysis at a temperature below the gelatinization temperature of the starch to effect a molecular size reduction while substantially retaining the granular form of the starch, reacting the hydrolyzed starch with a reducing agent under reaction conditions which prevent the dissolution of the granular starch, suspending the stabilized, hydrolyzed starch in a liquid medium comprising a water-miscible organic solvent, in which medium the hydrolyzed starch is substantially insoluble, reacting the stabilized, hydrolyzed starch in suspension with a starch hydroxyalkylating agent under basic pH conditions until a hydroxyalkylated starch having a molecular substitution within the range from about 0.3 to 0.9 is obtained. The granular form of the starch is retained throughout the process.

REFERENCES:
patent: 3523938 (1970-08-01), Hershenson et al.
patent: 3890300 (1975-06-01), Huchette et al.

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