Preparation of peptides with C-terminal proline amide

Details Preparation of peptides with C-terminal proline amide Preparation of peptides with C-terminal proline amide

1986-04-01

1987-11-24

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530307, 530313, 530315, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331, C07K 102, C07K 508, C07K 510, C07K 708, C07K 706, C07K 738, C07K 716, C07K 720

Patent

active

047090146

ABSTRACT:
A peptide with C-terminal proline amide is produced by reacting in aqueous solution a protein substrate having C-terminal prolyl-leucine, prolyl-isoleucine, prolyl-valine, or prolyl-phenylalanine with carboxypeptidase Y in the presence of ammonia. The ammonia is preferably generated by the aqueous reaction of an ammonium salt and an alkali. An example of the peptide product is human calcitonin.

REFERENCES:
patent: 4654302 (1987-03-01), Fritz et al.

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