Preparation of peptides

Details Preparation of peptides Preparation of peptides

1974-04-15

1978-01-03

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260349, 560158, C07C12504

Patent

active

040666840

ABSTRACT:
The preparation of the azide of a carboxylic acid by reacting the hydrazide of the acid with nitrous acid is facilitated by using the organic solvent-soluble complex of an alkali metal nitrite with an ethylene oxide or propylene oxide cyclic polymer as the nitrous acid source. The improvement is particularly useful as a means for making peptides by the coupling reaction of an amino acid ester or other derivative with an acid azide in an anhydrous reaction medium.

REFERENCES:
patent: 3562295 (1971-02-01), Pedersen
K. Kopple, "Peptides and Amino Acids," Benjamin, Inc., New York (1966), pp. 47-48.
M. Bodanszky and M. Ondetti, "Peptide Synthesis," Interscience, New York (1966), pp. 75-81.
E. Schroder and K. Lubke, "The Peptides," vol. 1, Academic Press, New York (1965), pp. 82-85.

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