Preparation of pepsin substantially devoid of proteolytic activi

Details Preparation of pepsin substantially devoid of proteolytic activi Preparation of pepsin substantially devoid of proteolytic activi

1992-11-06

1994-06-28

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

424 9466, 435212, 435226, C12N 950, C12N 964, C12N 948, A61K 3754

Patent

active

053246527

ABSTRACT:
A method for producing a composition having an inhibiting effect on production of tumor necrosis factor (TNF), and a method for inhibiting the production of TNF in vivo by administering the composition is provided. The composition comprises a solution of pepsin which has been rendered substantially proteolytically inactive by a series of sequential dialysis against running water, deionized water, and distilled water, respectively, for periods of time sufficient to substantially eliminate the proteolytic activity of the pepsin solution. The resulting composition is combined with a pharmaceutically acceptable carrier and administered in vivo to partially inhibit the production of TNF induced by a bacterial endotoxin.

REFERENCES:
patent: 414591 (1889-11-01), Russell
patent: 424357 (1890-03-01), Russell
patent: 454575 (1891-06-01), Webber
patent: 3026251 (1962-03-01), Wolf, Jr. et al.
Sigma catalogue, p. 604, Feb. 1983.

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