Preparation of penicillin procaine

Details Preparation of penicillin procaine Preparation of penicillin procaine

2005-08-11

2008-11-04

Berch, Mark L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Base salt formation of 3-position -cooh group

Reexamination Certificate

active

07446194

ABSTRACT:
A process for preparing penicillin G procaine comprises the steps of introducing inactive ingredients into a first mixing tank and sterilizing the mixture of inactive ingredients in the first mixing tank. A procaine hydrochloride is dissolved in a second mixing tank, and the contents of the second mixing tank are added to the first mixing tank through a sterile filter. A solution of penicillin G potassium is introduced to the first mixing tank through a sterile filter, and the contents of the first mixing tank are mixed so that the procaine hydrochloride reacts with the penicillin G potassium forming penicillin G procaine. The resulting suspension is transferred through a homogenizer to a holding tank and penicillin G procaine is filled into a container.

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Invensys APV, The Modern Art of Engineering, APV Homogenisers Rannie 55/Gaulin 55, Alberslund, Denmark, 2 pages, (2007).

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