Preparation of penciclovir or famciclovir

Details Preparation of penciclovir or famciclovir Preparation of penciclovir or famciclovir

1999-02-26

2000-07-25

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, C07D47318, C07D47332

Patent

active

060938196

ABSTRACT:
A process for preparing 2-amino-6-chloropurine or a 2-acylated derivative thereof, comprising reacting guanine or 2,9-diacylguanine with a chlorinating agent, in the presence of methyltriethylammonium chloride as phase transfer catalyst, and thereafter when necessary, removing the 9-acyl group by hydrolysis.

REFERENCES:
patent: 4736029 (1988-04-01), Harnden et al.
patent: 5075445 (1991-12-01), Jarvest et al.
patent: 5216161 (1993-06-01), Hanson
patent: 5389637 (1995-02-01), Igi
patent: 5434263 (1995-07-01), Hertzsch
patent: 5910589 (1999-06-01), Hanson
Secrist et al., "2-Fluoroformycin and 2-Aminoformycin.Synthesis and Biological Activity", J. Med. Chem., 28, pp. 1740-1742 (1985).
Translation of EP 433845 (1991).
Abstract of WO92/ 13859 (1992).

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