Preparation of pasteurized human plasminogen

Details Preparation of pasteurized human plasminogen Preparation of pasteurized human plasminogen

1985-04-11

1986-08-05

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435188, C12N 968, C12N 996

Patent

active

046043586

ABSTRACT:
This invention relates to a method for producing a plasminogen preparation which has been pasteurized to produce a hepatitis safe injectable plasminogen. The method comprises: adding to an aqueous solution of plasminogen the protective agent of methyl lysine ester, or ethyl lysine ester or a hydrochloride salt thereof which has antifibrinolytic acitivity to thereby attach the agent to plasminogen and form a modified plasminogen; and subjecting the resulting modified agent to a heat treatment of at least 60.degree. C. for at least 10 hours. Further, the protective agent may be separated from the modified plasminogen by affinity chromatography.

REFERENCES:
patent: 3066079 (1962-11-01), Hagan et al.
patent: 3227626 (1966-01-01), Baumgarten et al.
patent: 3340156 (1967-09-01), Jensen et al.
patent: 4442213 (1984-04-01), Heber et al.

Affiliated with

Also associated with

Rating

Preparation of pasteurized human plasminogen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of pasteurized human plasminogen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of pasteurized human plasminogen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-969008