Preparation of p-nitrophenyl-imidazoles

Details Preparation of p-nitrophenyl-imidazoles Preparation of p-nitrophenyl-imidazoles

1989-10-02

1991-04-16

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23360

Patent

active

050083988

ABSTRACT:
A process for the preparation of imidazoles which are substituted with p-nitrophenyl in the 2- and/or 4- and/or 5-position and may carry additional substituents, by reacting imidazoles which are substituted by phenyl in the 2- and/or 4- and/or 5-position and may carry additional substituents with mixtures of sulfuric acid and nitric acid, wherein the reaction is carried out in the presence of urea.

REFERENCES:
Van Es et al. J. Chem. Soc. 1363-1370 (1963).
Hurso Heterocycles 27, 371-376 (1988).
Japp et al, J. Chem., Soc. 462-472 (1886).
Davidson et al, J. Org. Chem. 2, 319-326 (1938)

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