Preparation of oxycodone

Details Preparation of oxycodone Preparation of oxycodone

2006-12-26

2006-12-26

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S044000

Reexamination Certificate

active

07153966

ABSTRACT:
A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of:a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixture to less than 6; and subsequentlyb) exposing the mixture to hydrogenation reagents for a period of at least 1 hour.

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Roland Kraβnig et al., “Optimization of the Synthesis of Oxycodone and 5-Methyloxycodone,”Arch. Pharm. Pharm. Med. Chem., vol. 329, 1996, pp. 325-326.

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