Preparation of oxamine complexes

Details Preparation of oxamine complexes Preparation of oxamine complexes

1987-06-11

1992-02-18

Rosen, Sam

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

128654, 1286532, 424 9, 436173, 556 1, 556 45, 556 50, 556110, 556113, 556116, 556138, C07F 1500, C07F 1502

Patent

active

050896440

ABSTRACT:
A process for making a solution of a complex of an oxamine and a polyvalent paramagnetic metal comprising contacting a solution of the oxamine with (a) the insoluble hydroxide of the polyvalent paramagnetic metal in water, or (b) an alkoxide of the metal is a non-aqueous solvent, thereby to form a solution of a complex of the oxamine and the metal. The complex, preferably ferrioxamine, is an improved NMR image enhancer compared even with ferrioxamine made conventionally, characterized by a high LD.sub.50.

REFERENCES:
patent: 3118823 (1964-01-01), Gaeumann et al.
patent: 3247197 (1966-04-01), Gaeumann et al.
patent: 3471476 (1969-10-01), Gaeumann et al.
patent: 4425319 (1984-01-01), Yokoyama et al.
patent: 4585780 (1986-04-01), Hider et al.
patent: 4637929 (1987-01-01), Quay
patent: 4647447 (1987-03-01), Gries et al.
patent: 4758422 (1988-07-01), Quay
J. Huberty, et al., The Society of Magnetic Resonance in Medicine, 1983, pp. 175-176.
Anderegg, et al.; Helv. Chim. Acta, 46; 1400-1407; 1963.
Hoffer, et al.; Radiology, 131; 775-779; 1979.
Merck Index, 9th Ed.; p. 374; No. 2837, Deferoxamine.
Chem. Absts.; 68:16758 Ln (Yunice, et al.), Arch. Environ. Health, 16 (2); 163-170 (19-68).
Carr, et al.; Clin. Radiol. 36; 561-568; 1985.

Affiliated with

Also associated with

Rating

Preparation of oxamine complexes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of oxamine complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of oxamine complexes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1825136