Preparation of ortho-aminobenzotrifluoride

Details Preparation of ortho-aminobenzotrifluoride Preparation of ortho-aminobenzotrifluoride

1983-09-07

1984-09-04

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564419, C07C 8500, C07C 8511

Patent

active

044698909

ABSTRACT:
This invention relates to a process for the preparation of ortho-aminobenzotrifluoride (OABT) from benzotrifluoride (BTF). The process provides an overall route employing non-isolation of intermediates which can be run smoothly and which results in the preparation of OABT in high yields with less contamination. This process includes a catalytic halogenation step in which BTF is converted to meta-halo BTF and other mono and di-halo isomers of BTF followed by nitration in the same reaction vessel under conditions which do not favor nitration of the di-halo isomers of BTF to produce a mixture which predominates in 5-halo-2-nitro BTF. In the final step the 5-halo-2-nitro BTF present is reduced and hydrodehalogenated with H.sub.2 in the presence of a catalyst to form OABT. Recyclable BTF is also obtained from the final reaction.

REFERENCES:
patent: 2772313 (1956-11-01), Trager
patent: 3073865 (1963-01-01), Spiegler
patent: 3359315 (1967-12-01), Kosak
patent: 3457310 (1969-07-01), Fischback et al.
patent: 3474144 (1969-10-01), Craig et al.

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