Preparation of optically clear serum

Details Preparation of optically clear serum Preparation of optically clear serum

1976-03-29

1977-08-30

Wolk, Morris O.

Chemistry: physical processes

Physical processes

Crystallization

252408, 260112B, G01N 3316

Patent

active

040451763

ABSTRACT:
A stable optically clear serum is prepared for use in the preparation of standards and quality control reference material for the assay of human serum components. In one aspect of the present invention, high density lipoproteins isolated from human blood serum are added to substantially human serum to produce a standard or reference material. A second aspect of the present invention involves the addition of isolated, non-primate lipoproteins to substantially human serum. The serum prepared as disclosed has good optical clarity upon lyophilization and reconstitution with aqueous media. Alternatively, the isolated lipoproteins are added in an aqueous diluent to lyophilized human serum.

REFERENCES:
patent: 3260648 (1966-07-01), Fox
patent: 3274062 (1966-09-01), Lou
patent: 3682835 (1972-08-01), Louderback
patent: 3764556 (1973-10-01), Kuchmak et al.
patent: 3955925 (1976-05-01), Proksch et al.
Jonas, J. Bio. Chem., vol. 247, No. 21, pp. 7767-7772, Nov. 1972.

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