Preparation of optically active spiro-hydantoins

Details Preparation of optically active spiro-hydantoins Preparation of optically active spiro-hydantoins

1992-02-18

1993-04-27

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546170, C07D21548, C07D47110

Patent

active

052063674

ABSTRACT:
This invention relates to the preparation of preparing optically-active asymmetric spiro-hydantoin compounds, which are known to be of value in the medical control of certain chronic diabetic complications arising from diabetes mellitus. This invention also includes within its scope certain corresponding novel amino and hydantoic acid compounds and the cinchonine salt of optically active hydantoic acid, which are used as intermediates in the aforesaid process.

REFERENCES:
patent: 4130714 (1978-12-01), Sarges
patent: 4345083 (1982-08-01), Rasmussen
patent: 4435578 (1984-03-01), Cue, Jr. et al.
patent: 4716113 (1987-12-01), Urban
patent: 4952694 (1990-08-01), Brackeen et al.
Journal of Organic Chemistry, vol. 47, p. 4081 (1982), Sarges et al.

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