Preparation of optically active cis-1,3-dibenzyl-hexahydro-1H-fu

Details Preparation of optically active cis-1,3-dibenzyl-hexahydro-1H-fu Preparation of optically active cis-1,3-dibenzyl-hexahydro-1H-fu

1984-02-13

1985-10-01

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

548303, 548321, C12P 1710, C07D491048

Patent

active

045446350

ABSTRACT:
A process for preparing an optically active cis-1,3-dibenzylhexahydro-1H-furo[3,4-d]imidazole-2,4-dione of the formula: ##STR1## wherein an asterisk (*) indicates an asymmetric carbon, Bzl represents a benzyl group and the 3a- and 6a-positions take the cis-configuration, which comprises reducing selectively an optically active cis-imidazolidinedicarboxylic acid monoester of the formula: ##STR2## wherein R is a C.sub.1 -C.sub.6 alkyl group and Bzl is as defined above with a reducing agent at either one of the carboxyl group and the alkoxycarbonyl group in the said monoester, followed by cyclization.

REFERENCES:
patent: 3700659 (1972-10-01), Gerecke et al.
patent: 4496739 (1985-01-01), Ohashi et al.
House, H., Modern Synthetic Reactions, 2nd Edition, Benjamin/Cummings, Menlo Park, CA, 1972, pp. 71, 77 and 78.
Iriuchijima, S., et al., Agric. Biol. Chem., 46(7), 1907-1910 (1982).
Iriuchijima, S., et al., Speech Given at Meeting of Association of Agricultural Chemistry of Japan, Apr. 1-4, 1982, Tokyo, Japan.

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