Preparation of optically active .alpha.-aryl propionic acids

Details Preparation of optically active .alpha.-aryl propionic acids Preparation of optically active .alpha.-aryl propionic acids

1992-12-23

1993-06-29

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562490, 562496, 562469, 562492, C07C 6206, C07C 53134, C07C 6333

Patent

active

052236404

ABSTRACT:
This invention provides a process to prepare optically active .alpha.-aryl propionic acids without the need for resolving a racemic mixture. In one embodiment of the process, an acetophenone is sequentially converted to a 1-alkyne, then to an .alpha.-aryl .beta.-silylated acrolein, and then to an acrylic acid, which is then asymmetrically hydrogenated to an optically active .alpha.-aryl propionic acid.

REFERENCES:
patent: 4135051 (1979-01-01), Walker et al.
patent: 4801719 (1989-01-01), Oertle
patent: 5097061 (1992-03-01), Shinizu et al.
patent: 5189208 (1993-02-01), Stahly

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