Preparation of optically active aliphatic carboxylic acids

Details Preparation of optically active aliphatic carboxylic acids Preparation of optically active aliphatic carboxylic acids

1992-01-24

1993-08-10

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

548531, 549 71, 558414, 560 9, 560 56, 560 59, 560 61, 560100, 560102, 560105, 560125, 560126, 560128, 560147, 560248, 562401, C07B 5700

Patent

active

052350959

ABSTRACT:
An improved process for the separation of enantiomers of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process involves: (i) forming a salt solution comprising said racemic mixture of a C.sub.1 to C.sub.6 linear or branched aliphatic carboxylic acid and an organic or inorganic base; (ii) treating said salt solution with one-half molar equivalent of a chiral organic nitrogenous base having a base strength no stronger than said organic or inorganic base; and (iii) precipitating from the reaction solution formed in step (ii) the less soluble diastereomeric salt, the improvement being adding to the salt solution of step (ii) an inert organic or inorganic base that is soluble in the salt solution.

REFERENCES:
patent: 4694100 (1987-09-01), Shimizu et al.
patent: 4723033 (1988-02-01), Erickson
patent: 4752417 (1988-06-01), Inoue et al.
patent: 4831147 (1989-05-01), Russell
patent: 4973745 (1990-11-01), Blaschke et al.
patent: 4983765 (1991-01-01), Lukas et al.
patent: 5015764 (1991-05-01), Manimaran et al.

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