Preparation of optically active aliphatic carboxylic acids

Details Preparation of optically active aliphatic carboxylic acids Preparation of optically active aliphatic carboxylic acids

1995-01-24

1996-11-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07B 5500

Patent

active

055741835

ABSTRACT:
A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises i) forming a diastereomeric salt by reaction comprising said racemic mixture of a C.sub.1 to C.sub.6 linear or branched aliphatic carboxylic acid and an amount of a chiral organic base sufficient to react with one of the enantiomers of the racemic mixture; ii) precipitating from the reaction solution formed in step i) the diastereomeric salt; iii) separating said precipitated diastereomeric salt; iv) decomposing the salt into its enantiomeric component and its organic base component; and v) isolating a substantially pure enantiomer from said decomposed salt.

REFERENCES:
patent: 4246193 (1981-01-01), Holton
patent: 4625054 (1986-11-01), Bernini
patent: 5380927 (1995-01-01), Paradies

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