Preparation of optically active 1,4-bridged-cyclohexane carboxyl

Details Preparation of optically active 1,4-bridged-cyclohexane carboxyl Preparation of optically active 1,4-bridged-cyclohexane carboxyl

1997-07-11

1998-06-09

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562401, 564302, 564303, 564460, C07C20988

Patent

active

057636478

ABSTRACT:
A process for preparing an optically active 1,4-bridged-cyclohexane carboxylic acid derivatives which are clinically important thromboxane A.sub.2 thromboxane of formula (IV): ##STR1## wherein, R is phenyl or phenyl substituted with hydroxy, lower alkoxy, halogen, or lower alkyl; Y is oxygen, methylene, substituted methylene; m is 0 or 1; n is 0, 1 or 2; q is 3 or 4 with the proviso that when m is 1, n is 0 or 1 from an optically active norbornyl amine derivative.

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