Preparation of opioid analgesics by a one-pot process

Details Preparation of opioid analgesics by a one-pot process Preparation of opioid analgesics by a one-pot process

2005-09-20

2005-09-20

Owens, Amelia Averill (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S039000

Reexamination Certificate

active

06946556

ABSTRACT:
A one-pot process for preparing opioid analgesics such as hydrocodone, hydromorphone, and analogues thereof by reacting codeine, morphine, and analogues thereof with hydrogen in a solvent system of benzophenone and neutral solvent in the presence of a metal catalyst followed by oxidation in the presence of potassium tert-alkylate.

REFERENCES:
patent: 2544291 (1951-03-01), Baiser
patent: 2649454 (1953-08-01), Rapoport
patent: 2654756 (1953-10-01), Homeyer
patent: 5366979 (1994-11-01), Lawson
patent: 5571685 (1996-11-01), Hailes et al.
patent: 5847142 (1998-12-01), Mudryk et al.
patent: 6008356 (1999-12-01), Kim et al.
patent: 6013796 (2000-01-01), Huang et al.
patent: 6235906 (2001-05-01), Sebastian
patent: 6365742 (2002-04-01), Mudryk et al.
patent: 6403798 (2002-06-01), Chiu et al.
patent: 6469170 (2002-10-01), Chiu et al.
patent: 6512117 (2003-01-01), Harclerode et al.
patent: 441613 (1927-03-01), None
patent: WO 0134608 (2001-05-01), None
Black, H.T. et al., Synthetic Communications, V. 30, No. 17, pp. 3195-3201, (2000), Copyright by Marcel Dekker, Inc.
Findlay, Stephen P. et al., Journal of the American Chemical Society, “The Preparation and Properties of Codeinone,” V. 72, pp. 3247-3249, Jul., 1950.
Mannich, C. et al., Arch. Pharm. “Ueber zwei neue Reduktionsprodukte des Kodeins,” V. 258, pp. 295-316, Selbatverlag des Deutschen Apotheker-Vereins, Berlin, (1920).
Rapoport, H. et al., The Journal of Organic Chemistry, “The Preparation of Some Dihydro Ketones in the Morphine Series by Oppenauer Oxidation, ” V. 15, No. 4, pp. 1103-1107, Jul., 1950, Published by The Williams & Wilkins Company, Baltimore, MD, USA.
Wieland, Heinrich, et al., Annalen der Chemie., vol. 433, pp. 267-271, (1923), Verlag Chemie, GmbH., Leipzig u. Berlin, printed in Germany.

Affiliated with

Also associated with

Rating

Preparation of opioid analgesics by a one-pot process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of opioid analgesics by a one-pot process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of opioid analgesics by a one-pot process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3374132