Chemistry of carbon compounds – Dipeptides – e.g. – aspartame – anserine – carnosine – etc.
Patent
1977-11-30
1980-01-15
Sutto, Anton H.
Chemistry of carbon compounds
Dipeptides, e.g., aspartame, anserine, carnosine, etc.
C07F 9165
Patent
active
041838807
ABSTRACT:
A process for the preparation of an O,O-dialkyl-S-(N-methylcarboxamidomethyl)-thiolphosphoric acid ester of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is alkyl, comprising reacting a salt of N-methylcarboxamidomethyl-thiosulphuric acid with an O,O-dialkyl phosphorous acid of the formula ##STR2## in a suspension in the presence of an alkaline earth metal alcoholate, alkali metal carbonate or alkaline earth metal carbonate, e.g. magnesium methylate or ethylate, calcium methylate or ethylate, potassium carbonate, sodium carbonate, magnesium carbonate or calcium carbonate. Advantageously R.sub.1 and R.sub.2 each independently has up to 4 carbon atoms, the N-methylcarboxamidomethyl-thiosulphuric acid salt is an alkali metal salt and the reaction is carried out in ethylene chloride or chloroform at a temperature of about 10.degree. to 40.degree. C. in the presence of triethylamine as catalyst.
REFERENCES:
patent: 3156718 (1964-11-01), Lorenz et al.
Pudovik et al, "J. Gen. Chem. U.S.S.R.," vol. 23, (1953), English translation, pp. 273-276.
Abramov et al, "J. Gen. Chem. U.S.S.R.," vol. 23, (1953), English translation, pp. 1061-1065.
Bayer Aktiengesellschaft
Sutto Anton H.
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